Effect of Aqueous Extract of Walnut Septum on Blood Glucose and Pancreatic Structure in Streptozotocin-Induced Diabetic Mouse

Authors

  • Farzaneh Dehghani shiraz university of medical sciences
  • Mohammadreza Panjehshahin
  • Tahereh Mashhoody shiraz university of medical sciences
Abstract:

Walnut is a medicinal plant that its different parts such as leaf, seed, root and green husk was shown to reduce blood glucose. In Iranian traditional medicine, septum of walnut shell (SWS) was recommended to reduce blood glucose. But this effect should be determined with scientific researches. Therefore, the aim of this study is to evaluate the effect of the aqueous extract of SWS on blood glucose and histopathological structure of pancreas. For this purpose, 41 male bulb/C mice 25-30 gm were divided into five groups. All the animals received IP injection of streptozotocin (STZ) (220 mg/kg). Two weeks later, the diabetic animals were received daily oral treatment of normal saline and aqueous extract of SWS (200, 400, 600 and 800 mg/kg) respectively for four weeks. Blood samples were taken from retro-orbital sinus before the start of the experiment and repeated each two week. At the end of experiment, the animals were sacrificed and the pancreatic tissues were fixed, prepared and stained by Hematoxylin-Eosin for light microscope studies. The results showed that in each group, the SWS extract reduced blood glucose in long time ( p < 0.05), but this effect was not dose-dependent between groups. This study also showed that the SWS extract had not any effect on pancreatic structure. It seems that aqueous extract of SWS may reduce blood glucose without any effect on pancreatic structure. However, more investigations should be done to clarify these results.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

effect of aqueous extract of walnut septum on blood glucose and pancreatic structure in streptozotocin-induced diabetic mouse

walnut is a medicinal plant that its different parts such as leaf, seed, root and green husk was shown to reduce blood glucose. in iranian traditional medicine, septum of walnut shell (sws) was recommended to reduce blood glucose. but this effect should be determined with scientific researches. therefore, the aim of this study is to evaluate the effect of the aqueous extract of sws on blood glu...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Effect of Alcoholic Extract of Ziziphora tenuior L on Blood Glucose and Lipid Profiles in Streptozotocin-Induced Diabetic Rats

Introduction: Diabetes is a common metabolic disorder associated with an increased risk of cardiovascular disease, disability, and mortality. The present study was conducted to evaluate the effects of alcoholic extract of Ziziphora tenuior L (ziziphora) plant on blood glucose and fat profiles in streptozotocin-induced diabetic rats. Materials and Methods: In this study, 40 male wistar rats were...

full text

Effect of Coriandrum sativum L. seeds on blood glucose in streptozotocin-induced diabetic rats

Diabetes mellitus is considered a serious endocrine syndrome. The prevalence of diabetes mellitus in the general population is greater than 6%. Many herbal medicines have been recommended for the treatment of diabetic. The present study was carried out to investigate the effect of the alcoholic extract seeds of Coriandrum sativum L. on blood glucose in streptozotocin-induced diabetic rats. The ...

full text

Effect of Coriandrum sativum L. seeds on blood glucose in streptozotocin-induced diabetic rats

Diabetes mellitus is considered a serious endocrine syndrome. The prevalence of diabetes mellitus in the general population is greater than 6%. Many herbal medicines have been recommended for the treatment of diabetic. The present study was carried out to investigate the effect of the alcoholic extract seeds of Coriandrum sativum L. on blood glucose in streptozotocin-induced diabetic rats. The ...

full text

Effect of Silymarin on Blood Glucose concentration and Pax4 Gene Expression and Histopathology of Pancreatic Tissue in Streptozotocin-Induced Diabetic Wistar Rats

Aim and Background: Considering the high rates of diabetes in Iran and the world and also due to the lower side effects of medicinal plants compared to industrial and chemical arbitrators, this study examined the effect of the active ingredient of tall moss (silymarin) on the expression of pax4 gene, one of the key genes for development and reconstruction of pancreatic beta cells.   Material ...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 11  issue 1

pages  10- 0

publication date 2012-10

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023